Matt LeBlanc ... Joey Tribbiani (47 episodes, 2004-2006)

Paulo Costanzo ... Michael Tribbiani (47 episodes, 2004-2006)

Drea de Matteo ... Gina Tribbiani (47 episodes, 2004-2006)

Andrea Anders ... Alex Garrett (46 episodes, 2004-2006)

Jennifer Coolidge ... Bobbie Morganstern (33 episodes, 2004-2006)

Miguel A. Núñez Jr. ... Zach (17 episodes, 2005-2006)

Ben Falcone ... Howard (17 episodes, 2004-2006)

Adam Goldberg ... Jimmy (8 episodes, 2005-2006)

Alex Ball ... Todd / ... (7 episodes, 2005-2006)

Tommy Perna ... Courier / ... (7 episodes, 2004-2006)

Mädchen Amick ... Sara (5 episodes, 2005)

Matt Letscher ... Eric Garrett / ... (5 episodes, 2004-2005)

Simon Helberg ... Seth (4 episodes, 2004-2006)

Matthew Mullany ... Carmen's Assistant / ... (4 episodes, 2004-2006)

Gregory Harrison ... Dean (4 episodes, 2005-2006)

Lucy Liu ... Lauren / ... (3 episodes, 2004-2005)

Richard Ruccolo ... Glen (3 episodes, 2005)

Danneel Harris ... Katie / ... (3 episodes, 2004-2005)

Nat Faxon ... Bodie (3 episodes, 2004-2005)

Colby Donaldson ... Gunnar (3 episodes, 2004-2005)

Paula Cale ... Abby / ... (3 episodes, 2005)

Rachel Quaintance ... Chris (3 episodes, 2005)

Kelly Preston ... Donna Di Gregorio (2 episodes, 2004)

Carmen Electra ... Herself (2 episodes, 2005-2006)

Davis Mikaels ... Jason (2 episodes, 2005)

Kevin P. Farley ... Drunk Santa / ... (2 episodes, 2004-2005)

Melanie Deanne Moore ... Marci (2 episodes, 2005-2006)

Valerie Azlynn ... Candace (2 episodes, 2005)

Rob Boltin ... Rick (2 episodes, 2005)

Carlos Gómez ... Director / ... (2 episodes, 2005)

Brian Gross ... Guy #2 / ... (2 episodes, 2005)

John Larroquette ... Benjamin Lockwood (2 episodes, 2005)

Kristen Miller ... Jenna (2 episodes, 2005)

Neil Flynn ... Father O'Neill (2 episodes, 2006)

Aalok Mehta ... Rajeev (2 episodes, 2006 )